Innovative Materials and Techniques for Osteochondral Repair
Horea Rareș Ciprian Benea
Materials Research Foundations Vol. 62
Publication Date 2019, 184 Pages
Print ISBN 978-1-64490-052-9 (release date November 30th, 2019)
ePDF ISBN 978-1-64490-053-6
DOI: 10.21741/9781644900536
The book presents research in treating focal joint cartilage defects. Lipoaspirate fluid (LAF) cells have important applications in such areas as orthopedics, general surgery, plastic and repair or vascular surgery. Also discussed are cartilage tissue regeneration therapies using collagen scaffolds and multipotent mesenchymal cells; this offers the possibility of making real “biological arthroplasties”. The regeneration of cartilage tissue by injecting stem cell concentrates gives hope to patients suffering from cartilage degradation.
Keywords
Biomaterials, Osteochondral Repair, Lipoaspirate Fluid (LAF) Cells, Arthrosis, Focal Joint Cartilage Defects, Physiopathology of Cartilage Lesions, Diagnosis of Cartilage Lesions, Treatment of Cartilage Lesions, Plastic Surgery, Vascular Surgery, Repair Surgery, Orthopedics, Biological Arthroplasties
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Table of Contents
Introduction 1
1. Normal articular cartilage 3
2. Physiopathology of cartilage lesions 13
3. Diagnosis of cartilage lesions 21
4. Treatment of cartilage lesions 26
5. Study 1. In vitro behavior of mesenchymal stem cells on different biomaterials 36
6. Study 2. Lipoaspirate fluid derived stem cells use for the treatment of cartilage defects. Pilot study on rabbit model 57
7. Study 3. Comparative assessment of the healing of focal lesions of articular cartilage on an animal model, by using stem cells from the iliac crest versus stem cells from adipose tissue 71
8. Study 4. Static analysis with finite elements on the sheep knee treated by osteochondral reconstruction 102
9. Study 5. Retrospective observational study on articular cartilage therapies performed in clinical practice 119
10. General Conclusions 140
Acknowledgements 144
References 145
ANNEX 8.1 166
ANNEX 8.2 167
ANNEX 8.3 168
Related sites:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206689/
About the author
Lect. Horea Rares Ciprian BENEA, MD, PhD, is a consultant in Orthopedics and Traumatology surgery with 14 years of experience and since 2019 he is the head of University Clinic of Orthopedics and Traumatology from Cluj-Napoca, Romania. He takes care of a great variety of osteo-articular traumatic and non-traumatic pathology, but his focus domains are: arthroscopy (shoulder and knee), joint replacement (shoulder, hip, knee), cartilage reconstruction surgery and autologous biological therapies (stem cells, PRP).
He holds a PhD in Medicine from the University of Medicine and Pharmacy “Iuliu Hatieganu” Cluj-Napoca. Since 2017 he is Lecturer at the Orthopedics and Traumatology Discipline from UMF “Iuliu Hatieganu” Cluj-Napoca, where he teaches the French, English and Romanian series of students. He is the founder of CBSO – Center of Biomedical Sciences applied in Orthopedics, an integrated clinical and academic center for multidisciplinary research, under the frame of the Medical University. Lect. Horea BENEA, MD PhD, has published widely more than 40 peer-reviewed papers, proceedings and abstracts, very appreciated and cited in the literature, and presented more than 35 oral communications or poster at international conferences. He has also experience in research projects as leader or team member. The publications cover a wide area of subjects, from clinical practice studies to top research in the domain of regenerative medicine, implant tolerance and osseointegration and osteochondral reconstruction by tissue engineering and autologous biological means, including here multipotent stem cells and collagen membranes. Apart this, the present area of research extended towards the domain of regenerative medicine, focusing on osteoarthritis treatment. His research activity was awarded by the Faculty of Medicine of UMF “Iuliu Hatieganu” Cluj-Napoca with the Award for Young Surgeons in 2013 and other three awards for communications presented.
His international networking includes membership in the Communication Workgroup of European Shoulder Associates (ESA) under the frame of European Society of Sports Traumatology, Knee Surgery and Arthroscopy (ESSKA), an active association for professionals of arthroscopy, sports medicine and reconstructive surgery. He is member of Scientific Committee and General Assembly of the Romania Society of Sports Trauma and Arthroscopy (SRATS).
