Earth-abundant metals-Based Therapeutics: Transport, Design, and Applications
Aisha Yasin, Urwa Muaaz, Irtaza Ashraf, Atifa Batool, Muhammad Ramzan Saeed Ashraf Janjua, Syed Ali Raza Naqvi
At present, a total of 76 elements have been systematically incorporated into compounds that have either obtained clinical approval or are employed for diagnostic and therapeutic purposes. The advanced analytical techniques and instruments in cellular and molecular biology, spanning proteomics and genomics, have the potential to significantly influence the development and application of essential elements for therapeutic and diagnostic objectives. This includes both stable and radioactive compounds. The use of abundant earth metals in the pharmaceutical industry is attracting considerable attention due to their potential in creating cost-effective, sustainable, and innovative therapeutic solutions. Furthermore, abundant earth metals often demonstrate unique and desirable chemical properties that can be leveraged in drug design and synthesis. However, challenges exist in identifying elemental speciation in biological ecosystems. The integration of abundant earth metals into drug development and manufacturing processes presents an opportunity to create more affordable, effective, and sustainable therapeutic solutions. This ultimately contributes to improved healthcare outcomes globally.
Keywords
Medicinal Inorganic Chemistry, Metal Based Drugs, Transition Metals, Metallopharmaceuticals, Earth Abundant Metal Complexes, Drug Development
Published online 9/10/2025, 18 pages
Citation: Aisha Yasin, Urwa Muaaz, Irtaza Ashraf, Atifa Batool, Muhammad Ramzan Saeed Ashraf Janjua, Syed Ali Raza Naqvi, Earth-abundant metals-Based Therapeutics: Transport, Design, and Applications, Materials Research Foundations, Vol. 179, pp 79-96, 2025
DOI: https://doi.org/10.21741/9781644903711-4
Part of the book on Applications for Earth-Abundant Transition Metals
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