Preparation and characterization of nanoparticles for encapsulation and delivery vehicles
Megdi Eltayeb
download PDFAbstract. This research creates nanoparticles that are tunable, have a high active ingredient content, and are highly encapsulated and controlled. We use model materials to determine the ethylcellulose-vanillin ratios as well as the effective processing conditions required for nanoparticle formation using ethylcellulose and vanillin as active ingredients. Nanoparticles with a mean size of 45 to 64 nm were prepared at a rate of approximately 1.3 million nanoparticles per minute using a different polymer:vanillin ratio. The encapsulation efficiency and loading of vanillin at different concentrations in nanoparticles from solutions ranged from 75 to 94 percent and 66.90 to 86.54 percent, respectively, indicating that the loading and encapsulation efficiency of the nanoparticles decreased as the amount of vanillin increased.
Keywords
Electrohydrodynamic, Polymer, Nanoparticles, Controlled Release, Encapsulation
Published online 8/10/2023, 7 pages
Copyright © 2023 by the author(s)
Published under license by Materials Research Forum LLC., Millersville PA, USA
Citation: Megdi Eltayeb, Preparation and characterization of nanoparticles for encapsulation and delivery vehicles, Materials Research Proceedings, Vol. 31, pp 165-171, 2023
DOI: https://doi.org/10.21741/9781644902592-18
The article was published as article 18 of the book Advanced Topics in Mechanics of Materials, Structures and Construction
Content from this work may be used under the terms of the Creative Commons Attribution 3.0 license. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI.
References
[1] Attaalmanan, E.M., Mohammed-Ahmed, H.K., Hussein, S.A., Farag, M., Eltayeb, M., Fragoon, A.: The Biostability of Gold Nanoparticles for Cancer Treatment. J. Clin. Eng. 45, 66–71 (2020).
[2] Woering, M.H., Depreitere, B., Vander Sloten, J.: Estimated and underreported parameters in report based vehicle-bicycle accident reconstructions have a significant influence. Accid. Anal. Prev. 150, 105903 (2021). https://doi.org/10.1016/j.aap.2020.105903
[3] Yahya, I., Eltayeb, M.: Computational Modeling of Gold Nanoparticle in Lung Cancer Photothermal Therapy. J. Clin. Eng. 44, 157–164 (2019).
[4] Atif, R., Yahya, I., Eltayeb, M.: Simulation of drug release from biodegradable and erodible polymers. In: Proceedings of the International Conference on Computer, Control, Electrical, and Electronics Engineering 2019, ICCCEEE 2019. pp. 1–6 (2019). https://doi.org/10.1109/ICCCEEE46830.2019.9071247
[5] Ahmed, L., Yahya, I., Eltayeb, M.: Computational modeling of drug release profiles from swellable polymeric nanoparticles. In: Proceedings of the International Conference on Computer, Control, Electrical, and Electronics Engineering 2019, ICCCEEE 2019. pp. 1–5 (2019). https://doi.org/10.1109/ICCCEEE46830.2019.9070894
[6] Ahmed, L., Atif, R., Eldeen, T.S., Yahya, I., Omara, A., Eltayeb, M.: Study the Using of Nanoparticles as Drug Delivery System Based on Mathematical Models for Controlled Release. Int. J. Latest Technol. Eng. Manag. Appl. Sci. 8, 52–56 (2019).
[7] Yahya, I., Atif, R., Ahmed, L., Eldeen, T.S., Omara, A., Eltayeb, M.: Utilization of solid lipid nanoparticles loaded anticancer agents as drug delivery systems for controlled release. Int. J. Eng. Appl. Sci. Technol. 3, 7–16 (2019).
[8] Eltayeb, M.: Nanoencapsulation of ethylvanillin using Electrohydrodynamic technology. IOP Conf. Ser. Mater. Sci. Eng. 1150, 012017 (2021). https://doi.org/10.1088/1757-899x/1150/1/012017
[9] Yahya, I., Atif, R., Ahmed, L., Eldeen, T.S., Omara, A., Eltayeb, M.: Polymeric Nanoparticles as Drug Delivery Systems for Controlled Release. Adv. Sci. Eng. Med. 12, 263–270 (2020).
[10] Eltayeb, M., Yahya, I.: Computational approaches for investigating different shapes of nanoparticles-based drug delivery. bioRxiv. (2020).
[11] Yahya, I., Eltayeb, M.: Modeling of nano-carriers for vascular-targeted delivery for blood clots treatment. BioRxiv. (2020).
[12] Yahya, I., Atif, R., Ahmed, L., Eldeen, T.S., Omara, A., Eltayeb, M.: Mathematical Modeling of Diffusion Controlled Drug Release Profiles from Nanoparticles. Int. J. Res. Sci. Innov. (IJRSI),. 6, 287–291 (2019).
[13] Eltaye, M., Saleh, M.E.: Edible hybrid coating for food applications. In: AIP Conference Proceedings. p. 20009. AIP Publishing LLC (2022).
[14] Eltayeb, M.: Preparation and Characterization of Electrosprayed Nanoparticles containing Ethyl Maltol Flavor. In: Materials Science Forum. pp. 131–136. Trans Tech Publ (2021).
[15] Eltayeb, M., Stride, E., Edirisinghe, M., Harker, A.: Electrosprayed nanoparticle delivery system for controlled release. Mater. Sci. Eng. C. 66, 138–146 (2016). https://doi.org/10.1016/j.msec.2016.04.001
[16] Eltayeb, M., Stride, E., Edirisinghe, M.: Electrosprayed core-shell polymer-lipid nanoparticles for active component delivery. Nanotechnology. 24, (2013). https://doi.org/10.1088/0957-4484/24/46/465604
[17] Eltayeb, M., Bakhshi, P.K., Stride, E., Edirisinghe, M.: Preparation of solid lipid nanoparticles containing active compound by electrohydrodynamic spraying. Food Res. Int. 53, 88–95 (2013). https://doi.org/10.1016/j.foodres.2013.03.047
[18] Eltayeb, M., Stride, E., Edirisinghe, M.: Preparation, characterization and release kinetics of ethylcellulose nanoparticles encapsulating ethylvanillin as a model functional component. J. Funct. Foods. 14, 726–735 (2015). https://doi.org/10.1016/j.jff.2015.02.036