Multiscale approach to decohesion in cell-matrix systems
Salvatore Di Stefano, Ariel Ramirez-Torres, Luca Bellino, Vincenzo Fazio, Gennaro Vitucci, Giuseppe Florio
download PDFAbstract. We propose a model for cell-matrix decohesion that highlights the role of elasticity in this process. In doing this, we specialize our previous study of focal adhesion, an integrin mediated structure that oversees and guides the mutual interactions between cells and the extracellular matrix. Specifically, we consider a two-scale asymptotic homogenization technique to study the multi-scale nature of decohesion. Thus, we are able to use micro-structural information available at length scales smaller than those at which focal adhesions are observed. Based on classical two-scale asymptotic techniques the proposed approach allows to define effective elastic coefficients encoding the intrinsic heterogeneous properties of both focal adhesions and extracellular matrix.
Keywords
Focal Adhesion, Decohesion, Two-Scale Asymptotic Homogenization
Published online 3/17/2022, 6 pages
Copyright © 2023 by the author(s)
Published under license by Materials Research Forum LLC., Millersville PA, USA
Citation: Salvatore Di Stefano, Ariel Ramirez-Torres, Luca Bellino, Vincenzo Fazio, Gennaro Vitucci, Giuseppe Florio, Multiscale approach to decohesion in cell-matrix systems, Materials Research Proceedings, Vol. 26, pp 47-52, 2023
DOI: https://doi.org/10.21741/9781644902431-8
The article was published as article 8 of the book Theoretical and Applied Mechanics
Content from this work may be used under the terms of the Creative Commons Attribution 3.0 license. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI.
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