Polymers in Tissue Engineering
Z.A. Abdul Hamid, M.M.S. Mohd Sabee, N.N.F. Nik Md Noordin Kahar, N.N.I. Ahmad Tajuddin
This chapter presented the numerous types of polymer biomaterial scaffolds for tissue engineering. The different types of clinical applications including bone, cartilage, skin, space filling scaffolds, and adipose tissue regeneration are discussed. Their fabrication techniques; conventional and emerging additive manufacturing for fabrication of the 3D scaffolds are also presented. A focus of hydrogel as scaffolds is discussed in detail. Meanwhile, the common interaction between biomaterials and cells are introduced to ensure the polymer biomaterial scaffolds developed are biocompatible and non-toxic so that the rejection after the implantation could be prevented. The discussed information in this chapter is essential to be considered in any development of a scaffold as an implant for tissue engineering.
Keywords
Tissue Engineering, Surgery, Polymer Scaffold, Polymer Implant
Published online 4/20/2022, 39 pages
Citation: Z.A. Abdul Hamid, M.M.S. Mohd Sabee, N.N.F. Nik Md Noordin Kahar, N.N.I. Ahmad Tajuddin, Polymers in Tissue Engineering, Materials Research Foundations, Vol. 123, pp 53-91, 2022
DOI: https://doi.org/10.21741/9781644901892-3
Part of the book on Applications of Polymers in Surgery
References
[1] The Ontario’s Organ and Tissue Donation Agency, Toronto, Canada: Annual Report 2009. URL https://www.giftonline.on.ca/page.cfm?id=93C7F131-0C19-48D7-BBBCD444069B220A (accessed 20 September 2021).
[2] Health Resources and Services Administration (HRSA): organdonor.gov 2020. URL https://www.organdonor.gov/learn/organ-donation-statistics/detailed-description#fig1 (accessed 20 September 2021).
[3] Langer, R.; Vacanti, J. P. Tissue Eng. 260 (1993) 920-926. https://doi.org/10.1126/science.8493529
[4] Langer, R. Tissue Eng. 13(1) (2007) 1-2. https://doi.org/10.1089/ten.2006.0219
[5] Ma, P. X. Mater. Today 7(5) (2004) 30-40. https://doi.org/10.1016/S1369-7021(04)00233-0
[6] Prime, E. L.; Hamid, Z. A.; Cooper-White, J. J.; Qiao, G. G. Biomacromolecules 8 (2007) 2416-2421. https://doi.org/10.1021/bm0702962
[7] Wacker, B. K.; Alford, S. K.; Scott, E. A.; Thakur, M. D.; Longmore, G. D.; Elbert, D. L. Biophys. J. 94(1) (2008) 273-285. https://doi.org/10.1529/biophysj.107.109074
[8] Shin, Y. M.; Kim, K. -S.; Lim, Y. M.; Nho, Y. C.; Shin, H. Biomacromolecules 9(7) (2008) 1772-1781. https://doi.org/10.1021/bm701410g
[9] Dikovski, D.; Bianco-Peled, H.; Seliktar, D. Biomaterials 27(8) (2006) 1496-1506. https://doi.org/10.1016/j.biomaterials.2005.09.038
[10] Nikolova, M. P.; Chalavi, M. S. Bioactive Materials 4 (2019) 271-292. https://doi.org/10.1016/j.bioactmat.2019.10.005
[11] Vats, A.; Tolley, N. S.; Polak, J. M.; Gough, J. E. Clinical of Otolaryngol 28(3) (2003) 165-172. https://doi.org/10.1046/j.1365-2273.2003.00686.x
[12] Hutcmacher, D. W. Biomaterials 21(24) (2000) 2529-2543. https://doi.org/10.1016/S0142-9612(00)00121-6
[13] Suh, J. K.; Matthew, H. W. Biomaterials 21(24) (2000) 2589-2598. https://doi.org/10.1016/S0142-9612(00)00126-5
[14] Liao, E.; Yaszemski, M.; Krebsbach, P.; Hollister, S. Tissue Eng. 13(3) (2007) 537-550. https://doi.org/10.1089/ten.2006.0117
[15] Wang, Y.; Kim, U. -J.; Blasioli, D. J.; Kim, H. -J.; Kaplan, D. L. Biomaterials 26(34) (2005) 7082-7094. https://doi.org/10.1016/j.biomaterials.2005.05.022
[16] Pattison, M.; Webster, T. J.; Leslie, J.; Kaefer, M.; Haberstroh, K. M. Macromol. Biosci. 7(5) (2007) 690-700. https://doi.org/10.1002/mabi.200600297
[17] Seal, B. L.; Otero, T. C.; Panitch, A. Mater. Sci. Eng. R. 34(4-5) (2001) 147-230. https://doi.org/10.1016/S0927-796X(01)00035-3
[18] Chan, B. P.; Leong, K. W. European Spine Journal 4 (2008) 467-479. https://doi.org/10.1007/s00586-008-0745-3
[19] Dhandayuthapani, B.; Yoshida, Y.; Maekawa, T.; Kumar, D. S. Int. J. Polym. Sci. (2011). https://doi.org/10.1155/2011/290602
[20] Yukna, R. A.; Yukna, C. N. J. Clin. Periodontol. 25(12) (1998) 1036-1040. https://doi.org/10.1111/j.1600-051X.1998.tb02410.x
[21] Yukna R. A. J. Periodontol. (1994) 177-185. https://doi.org/10.1902/jop.1994.65.2.177
[22] Petite H.; Viateau, V.; Bensaid, W.; Meunier, A.; de Pollak, C.; Bourguignon, M.; Oudina, K.; Sedel, L.; Guillemin, G. Nature Biotechnol. 18(9) (2000) 959-963. https://doi.org/10.1038/79449
[23] Guillemin, G.; Patat, J. L.; Fournie, J.; Chetail, M. J. Biomed. Mat. Res. 21(5) (1987) 557-567. https://doi.org/10.1002/jbm.820210503
[24] Piecuch, J. F.; Goldberg, A. J.; Shastry, C. V.; Chrzasnowski, R. B. J. Biomed. Mat. Res. 18(1) (1984) 39-45. https://doi.org/10.1002/jbm.820180106
[25] Ma, Z.; Gao, H.; Gong, Y.; Shen, J. J. Biomed. Mater. Res. Part B: Appl. Biomater. 67B(1) (2003) 610-617. https://doi.org/10.1002/jbm.b.10049
[26] Holland, T. A.; Mikos, A. G. Adv. Biochem. Eng. Biotechnol. 102 (2006) 161-185.
[27] Sawtell, R. M.; Kayser, M. V.; Downes, S. Cell Materials (1995) 63-71.
[28] Nehrer, S.; Breinan, H. A.; Ramappa, A.; Hsu, H. P.; Minas, T.; Shortkroff, S.; Sledge, C. B.; Yannas, I. V.; Spector, M. Biomaterials 19(24) (1998) 2313-2328.
[29] Risbud, M.; Ringe, J.; Bhonde, R.; Sittinger, M. Cell Transplantation 10(8) (2001) 755-763. https://doi.org/10.3727/000000001783986224
[30] Brown, A. N.; Kim, B. -S.; Alsberg, E.; M. S. E.; Mooney, D. J. Tissue Eng. 6(4) (2000) 297-305. https://doi.org/10.1089/107632700418029
[31] Huang, X.; Zhang, Y.; Donahue, H. J.; Lowe, T. L. Tissue Eng. 13(11) (2007) 2645-2651. https://doi.org/10.1089/ten.2007.0084
[32] Zhang, L.; Hu, J.; Athanasiou, A. Crit. Rev. Biomed. Eng. 37(1-2) (2009) 1-57. https://doi.org/10.1615/CritRevBiomedEng.v37.i1-2.10
[33] Richbourg, N. R.; Peppas, N. A.; Sikavitsas, V. I. J. Tissue Eng. Regen. Med. 13(8) (2019) 1275-1293. https://doi.org/10.1002/term.2859
[34] Dickinson, L. E.; Gerecht, S.; Front. Physiol. 7 (2016) 341. https://doi.org/10.3389/fpls.2016.00341
[35] Tottoli, E. M.; Dorati, R.; Genta, I.; Chiesa, E.; Pisani, S.; Conti, B. Pharmaceutics 12(8) (2020) 735. https://doi.org/10.3390/pharmaceutics12080735
[36] Drury, J. L.; Mooney, D. J. Biomaterials 24(24) (2003) 4337-4351. https://doi.org/10.1016/S0142-9612(03)00340-5
[37] Xu, L.; Liu, L.; Liu, F.; Cai, H.; Zhang, W. Polym. Chem. 6(15) (2015) 2945-2954. https://doi.org/10.1039/C5PY00039D
[38] Loebsack, A.; Greene, K.; Wyatt, S.; Culberson, C.; Austin, C.; Beiler, R.; Roland, W.; Eiselt, P.; Rowley, J.; Burg, K.; Mooney, D.; Holder, W.; Halberstadt, C. J. Biomed. Mater. Res. 57(4) (2001) 575-581. https://doi.org/10.1002/1097-4636(20011215)57:4<575::AID-JBM1204>3.0.CO;2-9
[39] VandeVord, P. J.; Matthew, H. W. T.; DeSilve, S. P.; Mayton, L.; Wu, B.; Wooley, P. H. J. Biomed. Mater. Res. 59(3) (2002) 585-590. https://doi.org/10.1002/jbm.1270
[40] Ono, K.; Saito, Y.; Yura, H.; Ishikawa, K; Kurita, A.; Akaike, T.; Ishihara, M. J. Biomed. Mater. Res. 49(2) (2000) 289-295. https://doi.org/10.1002/(SICI)1097-4636(200002)49:2<289::AID-JBM18>3.0.CO;2-M
[41] Zhao, X.; Kato, K.; Fukumoto, Y.; Nakamae, K. Int. J. Adhes. and Adhes. 21(3) (2001) 227-232. https://doi.org/10.1016/S0143-7496(01)00003-3
[42] Yao, Rui.; Zhang, Renji.; Yan, Y.; Wang, X.; Journal of Bioactive and Compatible Polymers 24(1) (2009) 48-62. https://doi.org/10.1177/0883911509103329
[43] Patrick, Jr. C. W. Semin. Surg. Oncol. 19(3) (2000) 302-311. https://doi.org/10.1002/1098-2388(200010/11)19:3<302::AID-SSU12>3.0.CO;2-S
[44] Gomillion, C. T.; Burg, K. J. L. Biomaterials 27(36) (2006) 6052-6063. https://doi.org/10.1016/j.biomaterials.2006.07.033
[45] Kononas, T. C.; Bucky, L. P.; Hurley, C. May, J. W. Plast. Reconstr. Surg., 91(5) (1993) 763-768. https://doi.org/10.1097/00006534-199304001-00001
[46] Bartynski, J.; Marion, M. S.; Wang, T. D. Otalaryngol Head Neck Surg. 102(4) (1990) 314-321. https://doi.org/10.1177/019459989010200402
[47] Sommer, B.; Sattler, G. Dermatol. Surg. 26(12) (2000) 1159-1166. https://doi.org/10.1046/j.1524-4725.2000.00278.x
[48] Kimura, Y.; Ozeki, M.; Inamoto, T.; Tabata, Y. Biomaterials 24(14) (2003) 2513-2521. https://doi.org/10.1016/S0142-9612(03)00049-8
[49] Vashi, A. V.; Keramidaris, E.; Abberton, K. M.; Morrison, W. A.; Wilson, J. L.; O’Connor, A. J.; Cooper-White, J. J.; Thompson, E. W. Biomaterials 29(5) (2008) 573-579. https://doi.org/10.1016/j.biomaterials.2007.10.017
[50] Flynn, L.; Woodhouse, K. A. Organogenesis 4(4) (2008) 228-235. https://doi.org/10.4161/org.4.4.7082
[51] Green, H.; Kehinde, O. Cell 7(1) (1976) 105-113. https://doi.org/10.1016/0092-8674(76)90260-9
[52] Green, H.; Meuth, M. Cell 3(2) (1974) 127-133. https://doi.org/10.1016/0092-8674(74)90116-0
[53] Kuri-Harcuch, W.; Green, H. Proc. Natl. Acad. Sci. USA 75(12) (1978) 6107-6109. https://doi.org/10.1073/pnas.75.12.6107
[54] Xu, F.; Gomillion, C. T.; Maxson, S.; Burg, K. J. L. J. Tissue Eng. Regen. Med. 3 (2009) 338-347. https://doi.org/10.1002/term.158
[55] Conrad, C.; Huss, R. J. Surg. Res. 124(2) (2005) 201-208. https://doi.org/10.1016/j.jss.2004.09.015
[56] Pelled, G. G. T.; Aslan, H.; Gazit, Z.; Gazit, D. Curr. Pharm. Des. 8(21) (2002) 1917-1928. https://doi.org/10.2174/1381612023393666
[57] Alhadlaq, A.; Tang, M.; Mao, J. J. Tissue Eng. 11(3-4) (2005) 556-566. https://doi.org/10.1089/ten.2005.11.556
[58] Keskar, V. B. S.; Marion, N. W.; Mao, J. J.; Gemeinhart, R. A. Tissue Eng. 15(7) (2009) 1695-1707. https://doi.org/10.1089/ten.tea.2008.0238
[59] Elisseeff, J.; Anseth, K.; Sims, D.; Mcintosh, W.; Randolph, M.; Yaremchuk, M.; Langer, R. Plast. Reconstr. Surg. 104(4) (1999) 1014-1022. https://doi.org/10.1097/00006534-199909020-00018
[60] Burdick, J. A.; Anseth, K. S. Biomaterials 23(22) (2002) 4315-4323. https://doi.org/10.1016/S0142-9612(02)00176-X
[61] Pradhan, S.; Hassani, I.; Seeto, W. J.; Lipke, E. A. J. Biomed. Mater. Res. A. 105(1) (2017) 236-252. https://doi.org/10.1002/jbm.a.35899
[62] Abberton, K. M.; Bortolotto, S. K.; Woods, A. A.; Findlay, M.; Morrison, W. A.; Thompson, E. W.; Messina, A. Cells Tissues Organs 188(4) (2008) 347-358. https://doi.org/10.1159/000121575
[63] Kawaguchi, N.; Toriyama, K.; Nicodemou-Lena, E.; Inou, K.; Torii, S.; Kitagawa, Y. Proc. Natl. Acad. Sci. USA 95(3) (1998) 1062-1066. https://doi.org/10.1073/pnas.95.3.1062
[64] Cronin, K. J.; Messina, A.; Knight, K. R.; et al. Plast. Reconstr. Surg. 113(1) (2004) 260-269. https://doi.org/10.1097/01.PRS.0000095942.71618.9D
[65] Chenite, A.; Chaput, C.; Wang, D.; Combes, C.; Buschman, M. D.; Hoemann, C. D.; Leroux, J. C.; Atkinson, B. L.; Binette, F.; Selmani, A. Biomaterials 21(21) (2000) 2155-2161. https://doi.org/10.1016/S0142-9612(00)00116-2
[66] Lee, K. Y.; Mooney, D. J. Chemical Reviews 101(7) (2001) 1869-1880. https://doi.org/10.1021/cr000108x
[67] Buckley, C. T.; O’Kelly, K. U. Topics in Biomechanical Engineering. Trinity Centre for Bioengineering (2004) p147-166.
[68] Balakrishnan, -B.; Jayakrishnan, A. Biomaterials 26(18) (2005) 3941-3951. https://doi.org/10.1016/j.biomaterials.2004.10.005
[69] Yoo, H. S.; Lee, E. A.; Yoon, J. J.; Park, T. G. Biomaterials 26(14) (2005) 1925-1933. https://doi.org/10.1016/j.biomaterials.2004.06.021
[70] Eiselt, P.; Lee, K. Y.; Mooney, D. J. Macromolecules 32(17) (1999) 5561-5566. https://doi.org/10.1021/ma990514m
[71] Lutoft, M. P.; Weber, F. E.; Schmoekel, H. G.; Schense, J. C.; Kohler, T.; Muller, R.; Hubbell, J. A. Nat. Biotechnol. 21(5) (2003) 513-518. https://doi.org/10.1038/nbt818
[72] Kim, S.; Healy, K. E. Biomacromolecules 4(5) (2003) 1214-1223. https://doi.org/10.1021/bm0340467
[73] Liu, C.; Xia, Z.; Chernuszka, J. T. Trans IChemE, Part A, Chemical Engineering Resaerch and Design 85(A7) (2007) 1051-1064. https://doi.org/10.1205/cherd06196
[74] Wong, W. H.; Mooney, D. J. Synthetic Biodegradable Polymer Scaffolds. Birkhauser Boston (1997) p 51-82. https://doi.org/10.1007/978-1-4612-4154-6_4
[75] Jagur-Grodzinski, J. Polym. Adv. Technol. 17(6) (2006) 395-418. https://doi.org/10.1002/pat.729
[76] Oh, S. H.; Kang, S. G.; Kim, E. S.; Cho, S. H.; Lee, J. H. Biomaterials 24(22) (2003) 4011-4021. https://doi.org/10.1016/S0142-9612(03)00284-9
[77] Pradny, M.; Lesny, P.; Fiala, J.; Vacik, J.; Slouf, M.; Michalek, J.; Sykova, E. Collect. Czech. Chem. Commun. 68(4) (2003) 812-822. https://doi.org/10.1135/cccc20030812
[78] Langer, R. J. Controlled Release 62 (1999) 7-11. https://doi.org/10.1016/S0168-3659(99)00057-7
[79] Mikos, A. G.; Thorsen, A. J.; Cherwonka, L. A.; Bao, Y.; Langer, R.; Winslow, D. N.; Vacanti, J. P. Polymer 35(5) (1994) 1068-1077. https://doi.org/10.1016/0032-3861(94)90953-9
[80] Lu, L.; Mikos, A. G. MRS Bulletin 21(11) (1996) 28-32. https://doi.org/10.1557/S088376940003181X
[81] Gao, J.; Crapo, P. M.; Wang, Y. Tissue Eng. 12(4) (2006) 917-925. https://doi.org/10.1089/ten.2006.12.917
[82] Nam, Y. S.; Park, T. G. J. Biomed. Mater. Res. 47(1) (1999) 8-17. https://doi.org/10.1002/(SICI)1097-4636(199910)47:1<8::AID-JBM2>3.0.CO;2-L
[83] Mikos, A. G.; Bao, Y.; Cima, L. G.; Ingeber, D. E.; Vacanti, J. P.; Langer, R. J. Biomed. Mater. Res. 27(2) (1993) 183-189. https://doi.org/10.1002/jbm.820270207
[84] Hou, Q.; Grijpma, D. W.; Feijin, J. Biomaterials 24(11) (2003) 1937-1947. https://doi.org/10.1016/S0142-9612(02)00562-8
[85] Nam, Y. S.; Park, T. G. Biomaterials 20(19) (1999) 1783-1790. https://doi.org/10.1016/S0142-9612(99)00073-3
[86] Dhariawala, B.; Hunt, E.; Boland, T. Tissue Eng. 10(9-10) (2004) 1316-1322. https://doi.org/10.1089/ten.2004.10.1316
[87] Gomes, M. E.; Ribeiro, A. S.; Malafaya, P. B.; Reis, R. L.; Cunha, A. M. Biomaterials 22(9) (2001) 883-889. https://doi.org/10.1016/S0142-9612(00)00211-8
[88] Freed, L. E.; Marquis, J. C.; Nohria, A.; Emmanual, J.; Mikos, A. G.; Langer, R. J. Biomed. Mater. Res. 27(1) (1993) 11-23. https://doi.org/10.1002/jbm.820270104
[89] Nam, Y. S.; Yoon, J. H.; Park, T. G. J. Biomed. Mater. Res. Part B. 53 (2000) 1-7. https://doi.org/10.1002/(SICI)1097-4636(2000)53:1<1::AID-JBM1>3.0.CO;2-R
[90] Draghi, L.; Resta, S.; Pirozzolo, M. G.; Tanzi, M. C. J. Mater. Sci.: Mater. in Med. 16 (2005) 1093-1097. https://doi.org/10.1007/s10856-005-4711-x
[91] Lo, H.; Ponticiello, M. S.; Leong, K. W. Tissue Eng. 1(1) (1995) 15-28. https://doi.org/10.1089/ten.1995.1.15
[92] Schugens, C.; Maquet, V.; Grandfils, C.; Jerome, R.; Teyssie, P. J. Biomed. Mater. Res. 30(4) (1996) 449-461. https://doi.org/10.1002/(SICI)1097-4636(199604)30:4<449::AID-JBM3>3.0.CO;2-P
[93] Mikos, A. G.; Temenoff, J. S. J. Biotechnol. 3(2) (2000) 114-119. https://doi.org/10.2225/vol3-issue2-fulltext-5
[94] Petrovic, V.; Vicente, J.; Ramn. J.; Portols, L. Biomedicine (2012).
[95] Rastogi, P.; Kandasubramanian, B. Chem. Eng. J. 366 (2019) 264-304. https://doi.org/10.1016/j.cej.2019.02.085
[96] Butt, J.; Bhaskar, R. J. Manuf. Mater. Process 4(2) (2020) 1-20.
[97] Gómez-Ciriza, G.; Hussain, T.; Gómez-Cía, T.; Valverde, I. Interv. Cardiol. 7(4) (2015) 343-350. https://doi.org/10.2217/ica.15.25
[98] Negi, S.; Dhiman, S.; Sharma, R. K. Rapid Prototyp. J. 20(3) (2014) 256-267. https://doi.org/10.1108/RPJ-07-2012-0065
[99] Ramola, M.; Yadav, V.; Jain, R. J. Manuf. Technol. Manag. 30(1) (2019) 48-69. https://doi.org/10.1108/JMTM-03-2018-0094
[100] Ghilan, A.; Chiriac, A. P.; Nita, L. E.; Rusu, A. G.; Neamtu, I.; Chiriac, V. M. J. Polym. Environ. 28(5) (2020) 1345-1367. https://doi.org/10.1007/s10924-020-01722-x
[101] Ursan, I.; Chiu, L.; Pierce, A. J. Am. Pharm. Assoc. 53(2) (2013) 135-44. https://doi.org/10.1331/JAPhA.2013.12217
[102] Jamróz, W.; Szafraniec, J.; Kurek, M.; Jachowicz, R. Pharm. Res. 35(9) (2018). https://doi.org/10.1007/s11095-018-2454-x
[103] Mertz, L. IEEE Pulse 4(6) (2013) 15-21. https://doi.org/10.1109/MPUL.2013.2279616
[104] Gross, B. C.; Erkal, J. L.; Lockwood, S. Y.; Chen, C.; Spence, D. M. Anal. Chem. 86(7) (2014) 3240-53. https://doi.org/10.1021/ac403397r
[105] Hoy, M. B. Med. Ref. Serv. Q. 32(1) (2013) 94-9.
[106] Cevik, U.; Kam, M. Journal of Nanomaterials (2020).
[107] Banks, B. J. IEEE Pulse 4(6) (2013) 22-6. https://doi.org/10.1109/MPUL.2013.2279617
[108] Schubert, C.; van Langeveld, M. C.; Danoso, L. A. Br. J. Ophthalmol. 98(2) (2014) 159-61. https://doi.org/10.1136/bjophthalmol-2013-304446
[109] Abdul Hamid, Z. A.; Ismail, H.; Ahmad, Z. Materials Science Forum 819 (2015) 361-366. https://doi.org/10.4028/www.scientific.net/MSF.819.361
[110] LaPorte, R. J., Hydrophilic Polymer Coatings for Medical Devices. Technomic Publishing Company, Lancaster, PA (1997) p 20.
[111] Shu, X. Z.; Liu, Y.; Palumbo, F. S.; Luo, Y.; Prestwich, G. D. Biomaterials 25(7-8) (2004) 1339-1348. https://doi.org/10.1016/j.biomaterials.2003.08.014
[112] Moschou, E. A.; Chopra, N.; Khatwani, S. L.; Ehrick, J. D.; Deo, S. K.; Bachas, L. G.; Daunert, S. Mater. Res. Soc. Symp. Proc. (2007) 952. https://doi.org/10.1557/PROC-0952-F05-02
[113] Ishaug-Riley, S. L.; Crane-Kruger, G. M.; Yaszemski, M. J.; Mikos, A. G. Biomaterials 19(15) (1998) 1405-1412. https://doi.org/10.1016/S0142-9612(98)00021-0
[114] Mikos, A. G.; Sarakinos, G.; Lyman, M. D.; Ingber, D. E.; Vacanti, J. P.; Langer, R. Biotechnol. Bioeng. 42(6) (1993) 716-723. https://doi.org/10.1002/bit.260420606
[115] O’Brien, F. J.; Harley, B. A.; Yannas, I. V.; Gibson, L. Biomaterials 25(6) (2004) 1077-1086.
[116] Boyan, B. D.; Hummert, T. W.; Dean, D. D.; Scwartz, Z. Biomaterials 17(2) (1996) 137-146. https://doi.org/10.1016/0142-9612(96)85758-9
[117] O’Brien, F. J.; Harley, B. A.; Yannas, I. V.; Gibson, L. J. Biomaterials 26(4) (2005) 433-441. https://doi.org/10.1016/j.biomaterials.2004.02.052
[118] Chang, B. S.; Lee, C. K.; Hong, K. S.; Youn, H. J.; Ryu, H. S.; Chung, S. S.; Park, K. W. Biomaterials 21(12) (2000) 1291-1298. https://doi.org/10.1016/S0142-9612(00)00030-2
[119] Ranucci, C. S.; Kumar, A.; Batra, S. P.; Moghe, P. V. Biomaterials 21(8) (2000) 783-793. https://doi.org/10.1016/S0142-9612(99)00238-0
[120] Brauker, J. H.; Carr-Brendel, W. E.; Martinson, L. A.; Crudele, J.; Johnston, W. D.; Johnson, R. C. J. Biomed. Mater. Res. 29 (1995) 1517-1524. https://doi.org/10.1002/jbm.820291208
[121] Wake, M. C.; Patrick, C. W.; Mikos A. G. Cell Transplantation 3(4) (1994) 586-597. https://doi.org/10.1177/096368979400300411
[122] Kumerta, M.; Heimburg, D. V.; Schoof, H.; Heschel, I.; Rau, G. Int. J. Artif. Organs 25(1) (2002) 67-73. https://doi.org/10.1177/039139880202500111
[123] Griffith, L. G. Acta Biomater. 48(1) (2000) 263-277. https://doi.org/10.1016/S1359-6454(99)00299-2
[124] Hakkarainen, M. Adv. Polym. Sci. 157 (2002) 113-118. https://doi.org/10.1007/3-540-45734-8_4
[125] Tessmar, J. K.; Gopferich, A. M. Macromolecular Science 7(1) (2007) 23-39. https://doi.org/10.1002/mabi.200600096
[126] Myung, D.; Koh, W.; Ko, J.; Hu, Y.; Carrasco, M.; Noolandi, J.; Ta, C. N.; Frank, C. W. Polymer 48(18) (2007) 5376-5387. https://doi.org/10.1016/j.polymer.2007.06.070
[127] Gong, J. P.; Katsuyama, Y.; Kurokawa, T.; Osada, Y. Adv. Mater. 15(14) (2003) 1155-1158. https://doi.org/10.1002/adma.200304907
[128] Yin, L.; Fei, L.; Tang, C.; Yin, C. Polym. Int. 56(12) (2007) 1563-1571. https://doi.org/10.1002/pi.2306
[129] Gupta, N.; Srivastava, A. K. Polym. Int. 35(2) (1994) 109-118. https://doi.org/10.1002/pi.1994.210350201
[130] Peng, H. T.; Martineau, L.; Shek, P. N. J. Mater. Sci. – Mater. Med. 18(6) (2007) 975-986. https://doi.org/10.1007/s10856-006-0088-8
[131] Bajpai, A. K.; Shrivastava, M. J. J. Macromol. Sci. Part A Pure Appl. Chem. A39(7) (2002) 667. https://doi.org/10.1081/MA-120004511
[132] Caliceti, P.; Veronese, F.; Schiavon, O.; Lora, S.; Carenza, M. Farmaco 47(3) (1992) 275-286.
[133] Hu, H.; Briggs, C. R.; Nguyen, T.; Tran, H.; Rossberg, E. PCT Patent 15521 (1998).
[134] Kopecek, J.; Yang, J. Polym. Int. 56(9) (2007) 1078-1098. https://doi.org/10.1002/pi.2253
[135] Tanaka, Y.; Gong, J. P.; Osada, Y. Prog. Polym. Sci. 30(1) (2005) 1-9. https://doi.org/10.1016/j.progpolymsci.2004.11.003
[136] Sachlos, E.; Reis, N.; Ainsley, C.; Derby, B.; Czernuszka, J. T. Biomaterials 24(8) (2003) 1487-1497. https://doi.org/10.1016/S0142-9612(02)00528-8
[137] Anderson, J. M.; Rodriguez, A.; Chang, D. T. Seminars in Immunology 20(2) (2008) 86-100. https://doi.org/10.1016/j.smim.2007.11.004
[138] Ratner, B. D. J. Controlled Release 78(1-3) (2002) 211-218. https://doi.org/10.1016/S0168-3659(01)00502-8
[139] Xia, Z.; Triffitt, J. T. Biomed. Mater. 1(1) (2006) R1-R9. https://doi.org/10.1088/1748-6041/1/1/R01
[140] Xia, Z.; Ye, H.; Choong, C.; Ferguson, D. J.; Platt, N.; Cui. Z.; Triffitt, J. T. J. Biomed. Mater. Res. 71A(3) (2004) 538-548. https://doi.org/10.1002/jbm.a.30185
[141] Zhao, Q.; Topham, N.; Anderson, J. M.; Hiltner, A.; Lodoen, G.; Payet, C. R. J. Biomed. Mater. Res. 25(2) (1991) 177-183. https://doi.org/10.1002/jbm.820250205
[142] Anderson, J. M. Annu. Rev. Mater. Res. 31 (2001) 81-110. https://doi.org/10.1146/annurev.matsci.31.1.81
[143] Leibovich, S. J.; Ross, R. Am. J. Pathol. 78(1) (1975) 71-100.
[144] Martin, P. Science 276(5309) (1997) 75-81. https://doi.org/10.1126/science.276.5309.75