Magnetic Nanomaterials for Bio-Sensors based on SERS Effect

Magnetic Nanomaterials for Bio-Sensors based on SERS Effect

Cixue Xu, Wenxian Wei, Chengyin Wang

The discovery of surface-enhanced Raman spectroscopy technology especially the magnetic nanoparticle-based SERS technology has promoted the detection of trace amounts of biomolecules. The magnetic action of the nanoparticles causes the analytes to aggregate together, which promotes the detection of small amounts of biomass. Compared to other detection systems, analytical results will be more easily interfered in the complex biomass systems. Fortunately, magnetic nanoparticles can separate the detectors by external magnetic fields to avoid interference from impurities. Magnetic nanoparticles are often used in noble metal recombination to greatly enhance SERS by synergy. Magnetic nanoparticle/precious metal composites combine the advantages of both to improve the SERS effect. Magnetic nanoparticle SERS substrates can detect specific biomass (such as bacteria, antibodies, cells, RNA, etc.) by modifying definite aptamers. In this review, the research progress of SERS and magnetic nanoparticle-based SERS detection mechanism are described in detail. At the same time, different structure magnetic nanoparticle including Fe, Ni, CoFe2O4 used as SERS substrates are introduced and compared in detail. Moreover, the magnetic nanoparticle-based SERS detection types of detected biomass are also discussed.

Keywords
Magnetic Nanoparticles, SERS, Biosensors, Nanocomposites, Applications

Published online 1/30/2020, 33 pages

Citation: Cixue Xu, Wenxian Wei, Chengyin Wang, Magnetic Nanomaterials for Bio-Sensors based on SERS Effect, Materials Research Proceedings, Vol. 66, pp 1-33, 2020

DOI: https://doi.org/10.21741/9781644900611-1

Part of the book on Magnetochemistry

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