Physical and Biological Properties of Biomaterials Intended for Bone Repair Applications
S.R. Gavinho, M.P.F. Graça, P.R. Prezas, C.C. Silva, F.N. Freire, A.F. Almeida, A.S.B. Sombra
Hydroxyapatite is a biomaterial which has attracted a great deal of attention because of its chemical similarity with the composition of the mineral phase of human bones – biologic hydroxyapatite. Among its most recurring applications are coatings for orthopedic and dental implants, maxillofacial surgery, otolaryngology, scaffolds for bone tissue engineering and application as powders in total hip and knee surgeries. On the other hand, bioactive glasses belonging to the system SiO2-P2O5-CaO-Na2O are reported to stimulate host bone regeneration at a higher rate than any other known biomaterial. In the present contribution, the essential and relevant physical and biological properties of these biomaterials will be discussed.
Keywords
Bioceramics, Hydroxyapatite, Mechanical Alloying, In vivo Bioactivity, Bioglass®
Published online 9/20/2019, 22 pages
Citation: S.R. Gavinho, M.P.F. Graça, P.R. Prezas, C.C. Silva, F.N. Freire, A.F. Almeida, A.S.B. Sombra, Physical and Biological Properties of Biomaterials Intended for Bone Repair Applications, Materials Research Foundations, Vol. 57, pp 1-22, 2019
DOI: https://doi.org/10.21741/9781644900390-1
Part of the book on Engineering Magnetic, Dielectric and Microwave Properties of Ceramics and Alloys
References
[1] Silver, F. and C. Doillon, Biocompatibility: Interactions and ImplantableMaterials., New York: VCH, (1989)
[2] Donaruma, L.G., Definitions in biomaterials., Amsterdam: Elsevier, (1987)
[3] Park, J., Biomaterials Science and Engineering., New York: Plenum Press, (1984)
[4] Hench., L.L. and J. Wilson, An Introduction to Bioceramics., Singapore: World Scientific Publishing Co. Pte. Ltd., (1993). https://doi.org/10.1142/9789814317351_0001
[5] Kakaiya, R., Miller, W.V. and Gudino, M.D., Tissue transplant-transmitted infections, Transfusion, 31 (1991) 277-284. https://doi.org/10.1046/j.1537-2995.1991.31391165182.x
[6] Stevens, M., Biomaterials for bone tissue engineering, Materials Today, 11 (2008) 18-25. https://doi.org/10.1016/S1369-7021(08)70086-5
[7] Aoki, H., Hydroxyapatite of great promise for biomaterials,Transactions of the JWRI, 17 (1998) 107-112
[8] Hench, L.L., et al., An Investigation of Bonding Mechanisms at the Interface of a Prosthetic Material.J. Biomed maters. Res,. 5 (1972) 117–141. https://doi.org/10.1002/jbm.820050611
[9] Cao, W. and L.L. Hench, Bioactive material,. Ceramics International, 22 (1996) 493-507. https://doi.org/10.1016/0272-8842(95)00126-3
[10] Lavernia, C. and J.M. Schoenung, CalciumPhosphate Ceramics as Bone Substitutes, Ceram.Bull,. 70 (1991) 95-100
[11] Sergo, V., Sbaizero, O. and Clarke, D.R., Mechanical and chemical consequences of the residualstresses in plasma sprayed hydroxyapatite coatings, Biomaterials, 18 (1997) 477-482. https://doi.org/10.1016/S0142-9612(96)00147-0
[12] Constantz, B.R., et al., Skeletal repair by in situ formation of the mineral phase of bon,. Science, 24 (1995) 1796-1799. https://doi.org/10.1126/science.7892603
[13] Hench, L.L. and J. Wilson, in An Introduction to Bioceramics, L.L. Hench and J. Wilson, Editors., Singapore: World Scientific Publishing Co. Pte. Ltd, (1993). https://doi.org/10.1142/2028
[14] Vogel, W. and W. Holand, The development of Bioglass Ceramics for medical applications, Angewandte Chemie International Edition, 26 (1987) 527-544. https://doi.org/10.1002/anie.198705271
[15] Pajamäki, K.J.J., et al., Bioactiveglass and glass-ceramic-coated hip endoprosthesis: experimental study in rabbit, J. Mater. Sci.: Mater. Medi., 6 (1995) 14-18. https://doi.org/10.1007/BF00121240
[16] Ohtsuki, C., T. Kokubo, and T. Yamamuro, Mechanism of apatite formation on CaO-SiO2-P2O5glasses in a simulated body fluid.Journal of Non-Crystalline Solids, 143 (1992) 84-92. https://doi.org/10.1016/S0022-3093(05)80556-3
[17] Posner, A.S., in Technology, Biological Functions, and Applications, J.R.V. Wazer, Editor., Interscience Publishers, Inc., New York, (1961)
[18] Mellor, J.M., Comprehensive Treatise on Inorganic and Theorical Chemistry, London: Longmans Green, (1922)
[19] Narasaraju, T.S.B. and D.E. Phebe, Some physico-chemical aspects of hydroxyapatite, J. Mater. Sci., 31 (1996) 1-21. https://doi.org/10.1007/BF00355120
[20] Mohammadi, S., et al., Cast titanium as implant material. Journal of Materials Science: Materials in Medicine, 6 (1995) 435-444. https://doi.org/10.1007/BF00123367
[21] Le Geros, R.Z. and J.P. LeGeros, in An Introduction Bioceramics, L.L. Hench and J. Wilson, Editors, Singapore: World Scientific Publishing Co. Pte. Ltd., (1993)
[22] Aza, P.N.D., et al., Bioceramics- somulated body fluid interfaces: pH and its influence of hydroxyapatite formation, Journal of Materials Science: Materials in Medicine, 7 (1996) 399-402. https://doi.org/10.1007/BF00122007
[23] Galliano, P.G. and J.M.P. Lopez, Thermal behaviour of bioactive alkaline-earth silicophosphate glasses. Materials Science:materials in medicine, 6 (1995) 353-359. https://doi.org/10.1007/BF00120304
[24] Holmes, R.E. and S.M. Roser, Poroushydroxyapatite as a bone graft substitute in alveolar ridge augmentation: ahistometric study, Int. Jour. Oral Maxilifac. Surg., 16 (1987) 718-728. https://doi.org/10.1016/S0901-5027(87)80059-0
[25] Lange, G.L.D., et al., A clinical, radiographic, and histological evaluation of permucosal dental implants of dense hydroxylapatite in dogs, J. DentRes., 68 (1989) 509-518. https://doi.org/10.1177/00220345890680031601
[26] Page, D.G. and D.M. Laskin, Tissue responseat the bone-implant interface in a hydroxylapatite augmented mandibular ridge, Jour. Oral Maxillofac Surg., 45 (1987) 356-358. https://doi.org/10.1016/0278-2391(87)90360-0
[27] Hench, L.L., Bioceramics: From Concept to Clini,. Journal of the American Ceramic Society, 74 (1991) 1487-1510. https://doi.org/10.1111/j.1151-2916.1991.tb07132.x
[28] Frame, J.W., P.G.J. Rout, and R.M. Browne, Human tissue response to porous hydroxyapatite implants, A case report. Int.Jour. Oral Maxilifac. Surg., 18 (1989) 142-144. https://doi.org/10.1016/S0901-5027(89)80111-0
[29] Stea, S., et al., Quantitative analysis of the bone-hydroxypatite coating interface, Journal of Materials Science: Materials in Medicine, 6 (1995) 455-459. https://doi.org/10.1007/BF00123370
[30] Wang, P.E. and T.K. Chaki, Hydroxyapatite films on silicon single crystals by a solution technique: texture, supersaturation and pH influence, Journal of Materials Science: Materials in Medicine, 6 (1995) 94-104. https://doi.org/10.1007/BF00120415
[31] Ducheyne P , S. Radin, M.Heughebaert, J.C.Heughebaert, Calcium phosphate ceramic coating on porous titanium: Effect of structure and composition on electrophoretic deposition, vacuum sintering and in vitro dissolution, Biomaterials, 19 (1990) 244-254. https://doi.org/10.1016/0142-9612(90)90005-B
[32] Ducheyne, P., et al., The effect of hydroxyapatite impregnation on skeletal bonding of porous coated implants. J. Biomed. Mater Res., 14 (1980) 225-237. https://doi.org/10.1002/jbm.820140305
[33] Ducheyne, P. and J.M. Cuckler, Bioactive ceramic prosthetic coating, Clin. Orthop. Relat. Res., 276 (1992) 102-14. https://doi.org/10.1097/00003086-199203000-00014
[34] Ducheyne, P. and K.E. Healy, The effect of plasma-sprayed calcium on the metal ion release from porous chromium alloys, Journal of Biomedical Materials Research, 22 (1988) 1137-1163. https://doi.org/10.1002/jbm.820221207
[35] Ogino, M. and L.L. Hench, Formation of calcium phosphate films on silicate glasses, J. Non-Cryst. Solids, 38 & 39 (1980) 673-678. https://doi.org/10.1016/0022-3093(80)90514-1
[36] Hill, R., Apatite-mullite glass-ceramics. J Mater Sci, 6 (1995) 311-318. https://doi.org/10.1007/BF00120298
[37] Yaszemski, M.J., et al., Evolution of bone transplantation: molecular, cellular and tissue strategies to engineer human bone, Biomaterials, 17 (1996) 175-185. https://doi.org/10.1016/0142-9612(96)85762-0
[38] Liu, H.S., et al., Hydroxyapatite synthesized by a simplified hydrothermal method. Ceram. Int., 23 (1997) 19-25. https://doi.org/10.1016/0272-8842(95)00135-2
[39] Fernades, G.F. and M.C.M. Laranjeira, Calcium Phosphate Biomaterials from Marine Alga, Hydrothermal Synthesis and Characterisation, Química Nova, 23 (2000) 441-446. https://doi.org/10.1590/S0100-40422000000400002
[40] Bet, M.R., G. Goissis, and A.M.D.G. Plepis, Compósitos Colágeno Aniônico: Fosfato de Cálcio, Preparação e Caracterização. Química Nova, 20 (1997) 475-477. https://doi.org/10.1590/S0100-40421997000500006
[41] Heimke, G., Advanced ceramics for biomedical application.Angewandte Chemie, 101 (1989) 111-116. https://doi.org/10.1002/ange.19891010141
[42] Rhee, S.H. and J. Tanaka, Hydroxyapatite coating on a collagen membrane by a biomimetic method, J. Am. Ceram. Soc., 81 (1998) 3029-3031. https://doi.org/10.1111/j.1151-2916.1998.tb02734.x
[43] Doi, Y., et al., Formation of apatite-collagen complexes, J. Biomed. Mater. Res., 31 (1996) 43-49. https://doi.org/10.1002/(SICI)1097-4636(199605)31:1<43::AID-JBM6>3.0.CO;2-Q
[44] Bigi, A., S. Panzavolta, and N. Roveri, Hydroxyapatite-gelatin films: a structural and mechanical characterization. Biomaterials, 19 (1998) 739-744. https://doi.org/10.1016/S0142-9612(97)00194-4
[45] Liu, Q., J.R.D. Winjn, and C.A.V. Blitterswijk, Covalent bonding of PMMA, PBMA and poly(HEMA) to hydroxyapatite particles, J. Biomed. Mater. Res., 40 (1998) 257-263. https://doi.org/10.1002/(SICI)1097-4636(199805)40:2<257::AID-JBM10>3.0.CO;2-J
[46] Nimni, M.E. and R.D. Harkness, Collagen: Biochemistry, biomechanics, biotechnology, United States: CRC Press, 1 (1988)
[47] Nimni, M.E., Collagen: Biochemistry, biomechanics, biotechnology, United States: CRC Press, 3 (1988)
[48] Fukada, E., in Ferroelectric Plymers: Chemistry, Physics and Application, H.S. Nalwa, Editor, Marcel Dekker, Inc.: New York, (1995)
[49] Mascarenhas, S., in Topics in Applied Physics, Springer-Verlag: Berlin, (1987)
[50] Catauroa, M., A. Dell’Erab, and S.V. Cipriotic, Synthesis, structural, spectroscopic and thermoanalytical study ofsol–gel derived SiO2–CaO–P2O5 gel and ceramic materials, Thermochimica Acta, 625 (2016) 20-27. https://doi.org/10.1016/j.tca.2015.12.004
[51] Nandi, S.K., B. Kundu, and S. Datta, Development and Applications of Varieties of Bioactive Glass Compositions in Dental Surgery, Third Generation Tissue Engineering, Orthopaedic Surgery and as Drug Delivery System, Biomaterials Applications for Nanomedicine, 4 (2011) 69-116
[52] Jones, J.R., et al., Bioglass and Bioactive Glasses and Their Impact on Healthcare, International Journal of Applied Glass Science, 7 (2016) 423-434. https://doi.org/10.1111/ijag.12252
[53] Kaur, G., et al., A review of bioactive glasses: Their structure, properties, fabrication, and apatite formatio, Journal of Biomedical Materials Research Part A, 102 (2014) 254-274. https://doi.org/10.1002/jbm.a.34690
[54] Krishnan, V. and T. Lakshmi, Bioglass: A novel biocompatible innovation, J Adv Pharm Technol Res., 4 (2013) 78-83. https://doi.org/10.4103/2231-4040.111523
[55] Hench, L., The story of Bioglass, J Mater Sci: Mater Med, 17 (2006) 967-978. https://doi.org/10.1007/s10856-006-0432-z
[56] Crovace, M.C., et al., Biosilicate – A multipurpose, highly bioactive glass-ceramic. In vitro, in vivo and clinical trialsBiosilicate – A multipurpose, highly bioactive glass-ceramic,In vitro, in vivo and clinical trials,Journal of Non-Crystalline Solids, 432 (2016) 90-110. https://doi.org/10.1016/j.jnoncrysol.2015.03.022
[57] Bramhill, J., S. Ross, and G. Ross, Bioactive Nanocomposites for Tissue Repair and Regeneration: A Revie, Int. J. Environ. Res. Public Health, 14 (2017) 1-21. https://doi.org/10.3390/ijerph14010066
[58] Peitl, O., et al., Compositional and microstructural design of highly bioactive P2O5-Na2O-CaO-SiO2 glass-ceramic,Acta Biomaterialia, 8 (2012) 321-332. https://doi.org/10.1016/j.actbio.2011.10.014
[59] Martınez, A., I. Izquierdo-Barba, and M. Vallet-Regi, Bioactivity of a CaO-SiO2 Binary Glasses System, Chemistry Materials, 12 (2000) 3080-3088. https://doi.org/10.1021/cm001107o
[60] Jones, J.R., Review of bioactive glass: From Hench to hybrids, Acta Biomaterialia, 9(2013) 4457-4486. https://doi.org/10.1016/j.actbio.2012.08.023
[61] Rahaman, M.N., et al., Bioactive glass in tissue engineering, Acta Biomater., 7 (2011) 2355–2373. https://doi.org/10.1016/j.actbio.2011.03.016
[62] Hongxin, W., et al., Preparation and Characterization of the System SiO2-CaOP2O5 Bioactive Glasses by Microemulsion Approach, Journal of Wuhan University of Technology-Mater. Sci. Ed., 28 (2013) 1053-1057. https://doi.org/10.1007/s11595-013-0818-y
[63] Lee, J.-H., S.-J. Seo, and H.-W. Kim, Bioactive glass-based nanocomposites for personalized dental tissue regeneration, Dent Mater J, 35(5) (2016) 710-720. https://doi.org/10.4012/dmj.2015-428
[64] Mabrouk, M., et al., Comparative Study of Nanobioactive Glass Quaternary System 46S6, Bioceramics Development and Applications, 4 (2014) 1-4
[65] Mezahi, F.-Z., et al., Reactivity kinetics of 52S4 glass in the quaternary system SiO2–CaO–Na2O–P2O5: Influence of the synthesis process: Melting versus sol–gel, Journal of Non-Crystalline Solids, 361 (2013) 111-118. https://doi.org/10.1016/j.jnoncrysol.2012.10.013
[66] Gestel, N.A.P.V., et al., Clinical Applications of S53P4 Bioactive Glass in Bone Healing and Osteomyelitic Treatment: A LiteratureReview, BioMed Research International, (2015) 1-12. https://doi.org/10.1155/2015/684826
[67] Forsback, A.-P., S. Areva, and J.I. Salonen, Mineralization of dentin induced by treatment with bioactive glass S53P4 in vitro, Acta Odontol Scand, 62 (2004) 14-20. https://doi.org/10.1080/00016350310008012
[68] Bizari, D., et al., Synthesis, characterization and biological evaluation of sol-gel derived nanomaterial in the ternary system 64 % SiO2 – 31 % CaO – 5 % P2O5as a bioactive glass: in vitro, Ceramics – Silikáty, 67 (2013) 201-209
[69] Liu, J. and X. Miao, Sol–gel derived bioglass as a coating material for porous aluminascaffolds, Ceramics International, 30 (2004) 1781-1785. https://doi.org/10.1016/j.ceramint.2003.12.120
[70] Ma, J., et al., Influence of the sintering temperature on the structural feature and bioactivity of sol–gel derived SiO2–CaO–P2O5 bioglass, Ceramics International, 36 (2010) 1911–1916. https://doi.org/10.1016/j.ceramint.2010.03.017
[71] Mortazavi, V., et al., Antibacterial effects of sol-gel-derived bioactive glass nanoparticle onaerobic bacteria, Journal of Biomedical Materials Research Part A, 94 (2010) 160-168. https://doi.org/10.1002/jbm.a.32678
[72] Saravanapavan, P., et al., Bioactivity of gel– glass powders in the CaO-SiO2 system: A comparison with ternary (CaO-P2O5-SiO2) andquaternary glasses (SiO2-CaO-P2O5-Na2O), Journal of Biomedical Materials Research Part A, 66 (2003) 110-119. https://doi.org/10.1002/jbm.a.10532