Enzymatic Biosensor for in vivo Applications
Pedro Salazar, Miriam Martín, José Luis González–Mora
A large number of analytical devices have recently been developed for detecting biomarkers without the need for laboratory handling procedures. At present, there is a growing demand for developing minimal–or non–invasive implantable devices able to measure in real–time with high spatial resolution. Among the different approaches, implantable biosensors are the most common approach thanks to their high sensitivity and selectivity, the simplicity of starting materials and their cost-effectiveness because they can be easily miniaturized for the manufacture of implantable devices. This chapter reviews the main issues (sensitivity, selectivity, tolerance to fluctuations in oxygen levels, biocompatibility, long-term functional stability, etc.) involved in the design phase and the application of biosensors for in vivo monitoring of key molecules in health applications.
Keywords
Biosensor, in vivo, Enzyme, Amperometric Detection, Biocompatibility, Point–of–Care, Glucose, Lactate, Glutamate, Diabetes
Published online 3/25/2019, 28 pages
Citation: Pedro Salazar, Miriam Martín, José Luis González–Mora, Enzymatic Biosensor for in vivo Applications, Materials Research Foundations, Vol. 47, pp 289-316, 2019
DOI: https://doi.org/10.21741/9781644900130-8
Part of the book on Biosensors
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