Role of Nanoparticles in Combating Infections

Role of Nanoparticles in Combating Infections

Kanwal Rehman, Muhammad Sajid Hamid Akash

Infections still remain a serious threat to human beings globally. Bacterial infections are one of the major causes of deaths worldwide and increase the overall medical costs, mortality and morbidity due to the development of antimicrobial resistance by means of different mechanisms. Complications related to infectious diseases are being increased day by day, more particularly in developing countries due to limited resources and less availability of the choice of antimicrobial agents. The excessive use of antimicrobial agents creates drug resistance into the pathogens, which demand additional efforts to develop advanced and more effective therapeutic strategies to prevent and treat such kind of infections. So, there was an urgent need to develop new strategies and therapies to cure microbial infections. In response to this need, pharmaceutical scientists are trying their best to design such materials that enhance the biological activity and pharmacokinetic properties of antimicrobial agents against microbial infections. Currently, the best available strategy that can be implemented to prevent the development of drug resistance in pathogens is nanoparticle-based delivery of antimicrobial agents in order to enhance the effectiveness of antimicrobial agents against infections. Nanoparticles have experimentally been proven to have a wide range of antimicrobial potential against various pathogens and an ideal carrier system for intracellular delivery of antimicrobial agents. In this chapter, we have comprehensively summarized the role of polymeric-based nanoparticles for combating the infectious diseases.

Keywords
Antimicrobial Agents, Infections, Polymers, Nanoparticles, Delivery System

Published online 3/25/2019, 30 pages

Citation: Kanwal Rehman, Muhammad Sajid Hamid Akash, Role of Nanoparticles in Combating Infections, Materials Research Foundations, Vol. 47, pp 211-240, 2019

DOI: https://doi.org/10.21741/9781644900130-6

Part of the book on Biosensors

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